De sykdomsmodifiserende legemidlene brukes gjerne i kombinasjon med symptomlindrende legemidler som betennelsesdempende- og smertestillende legemidler.Opioider er sterke smertestillende medisiner som inneholder morfin eller lignende stoffer. De brukes mot sterke, akutte og kroniske smerter. Opioider virker gjennom å påvirke nerveceller i ryggmarg
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